Prevention of ventilator-associated pneumonia by selective decontamination of the digestive tract

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Prevention of ventilator-associated pneumonia by selective decontamination of the digestive tract.

We read with interest the review entitled ‘‘Evidence on measures for the prevention of ventilator-associated pneumonia’’ by LORENTE et al. [1]. We enjoyed the paper as it is comprehensive and based on an appropriate design. In particular, we welcome the authors’ acknowledgement of the proven clinical benefits of selective decontamination of the digestive tract (SDD). The authors give four expla...

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Selective decontamination of the digestive tract and ventilator-associated pneumonia (part 1).

resistance in esophageal resection. Intensive Care Med 1990;16 Suppl 3:S224–228. 28. van der Voort PH, van Roon EN, Kampinga GA, Boerma EC, Gerritsen RT, Egbers PH, Kuiper MA. A before-after study of multiresistance and cost of selective decontamination of the digestive tract. Infection 2004; 32(5):271–277. 29. Diez-Roux AV. Bringing context back into epidemiology: variables and fallacies in mu...

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Selective Decontamination of the Digestive Tract Reduces Pneumonia and Mortality

Selective decontamination of the digestive tract (SDD) has been subject of numerous randomized controlled trials in critically ill patients. Almost all clinical trials showed SDD to prevent pneumonia. Nevertheless, SDD has remained a controversial strategy. One reason for why clinicians remained reluctant to implement SDD into daily practice could be that mortality was reduced in only 2 trials....

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Selective decontamination of the digestive tract.

Ventilator-associated pneumonia usually originates from the patient's oropharyngeal microflora. In selective digestive decontamination, topical antibiotics are applied to the oropharynx and stomach for prevention of pneumonia and other infections, possibly reducing infection-related mortality. Selective digestive decontamination is also used for the prevention of gut-derived infections in acute...

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Lack of impact of selective digestive decontamination on Pseudomonas aeruginosa ventilator-associated pneumonia: benchmarking the evidence base.

BACKGROUND The selective digestive decontamination (SDD) component antibiotics have activity against Pseudomonas aeruginosa, an important ventilator-associated pneumonia (VAP) isolate. Evaluating the relationship between the anti-pseudomonal activity of SDD towards its VAP prevention effect is complicated by postulated indirect effects of SDD mediated in the concurrent control groups. The objec...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2008

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00023808